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Women allocated magnesium sulphate had a 52%lower risk of recurrent convulsions(95%CI 64%to 37%reduction)than those allocated diazepam(60[13. 2%])vs 126[27.9%];ie,14.7[SD 2.6]fewer women with recurrent convulsions per 100 women;2<0.00001).Maternal mortality was non-significantly lower among women allocated magnesium sulphate.There were no significant differences in other measures of serious maternal morbidity,or in perinatal morbidity or mortality.Women allocated magnesium sulphate had a 67%lower risk of recurrent convulsions(95%CI 79%to 47%reductions)than those allocated phenytoin(22[5.7%]vs 66[17.1%]ie,11.4[SD 2.2]fewer women with recurrent convulsions per 100 women;2p,0.00001).Maternal mortality was non-significantly lower among women allocated magnesium sulphate.Women allocated magnesium sulphate were also less likely to be ventilated,to develop pneumonia,and to be admitted to intensive care facilities than those allocated phenotoin.The babies of women who had been allocated magnesium sulphate before delivery were significantly less likely to be intubated at the place of delivery,and to be admitted to a special care nursery,than the babies of mothers who had been allocated phenytoin.There is now compelling evidence in favour of magnesium sulphate,rather than diazepam or phenytoin,for the treatment of eclampsia. |
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anticonvulsants
dilantin
eclampsia
magnesium sulfate
postpartum
pre-eclampsia
seizure
seizure,peripartum
seizure,pregnancy
seizure,treatment of
treatment of neurologic disorder
valium
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